PowerGlow Drips, also known as LIV Drips, are intravenous (IV) therapy treatments designed to nourish and rejuvenate the skin from within. These drips deliver a potent blend of glutathione, vitamins, antioxidants, and hydrating agents directly into the bloodstream for maximum absorption and effectiveness. This treatment is highly effective in reducing pigmentation, evening out skin tone, and enhancing overall skin radiance by detoxifying the body and promoting skin cell renewal.

PowerGlow IV Drips for pigmentation deliver high-dose glutathione, vitamin C, and alpha-lipoic acid directly into the bloodstream to suppress melanin production from within. At Claire Derma, our pigmentation drip formulation centres on intravenous glutathione at 1200mg to 1800mg per session — a dose that shifts melanin synthesis from eumelanin (dark brown-black pigment) toward pheomelanin (lighter yellow-red pigment) by inhibiting the tyrosinase enzyme.

Unlike oral supplements, which have limited absorption, IV therapy ensures 100% bioavailability of essential nutrients. The infusion works by:

Detoxification & Free Radical Removal – Detoxifying the body and flushing out free radicals that cause pigmentation.

Melanin Reduction – Reducing melanin production, leading to a brighter and more even skin tone.

Hydration & Skin Texture Improvement – Providing deep hydration, improving overall skin texture and suppleness.

Collagen Boost & Skin Rejuvenation – Boosting collagen synthesis, helping in long-term skin health and rejuvenation.

IV Glutathione (1200-1800mg) – At intravenous doses, glutathione achieves plasma levels that directly inhibit tyrosinase activity and shift melanin production toward lighter pheomelanin.

Vitamin C (5-10g) – High-dose IV vitamin C reduces the oxidised form of melanin precursors, lightening existing pigment while inhibiting new melanin formation.

Alpha-Lipoic Acid – A versatile antioxidant that functions in both water and fat-soluble environments, alpha-lipoic acid recycles both vitamin C and glutathione.

The pigmentation-focused PowerGlow formulation is distinct from our anti-aging drip. While both contain antioxidants, the pigmentation protocol prioritises ingredients with direct tyrosinase-inhibiting and melanin-modulating properties. Glutathione is the centrepiece — it inhibits tyrosinase both directly and through its antioxidant action, reducing the oxidative stress that stimulates melanocytes.

Oxidative Stress Reduction – Neutralizing oxidative stress, which contributes to skin discoloration.

Liver Detoxification – Enhancing liver detoxification, helping the body eliminate toxins that cause pigmentation.

Melanin Inhibition – Inhibiting melanin synthesis, leading to gradual skin brightening.

Cellular Repair & Skin Tone Enhancement – Supporting cellular repair, improving overall skin health and tone.

Graduated Dosing Protocol – Starting at a lower glutathione dose and increasing gradually minimises the risk of detoxification symptoms — headache, mild nausea — that can occur when large doses are introduced suddenly.

Weekly Frequency for Initial Course – Glutathione is metabolised rapidly, so weekly sessions during the initial phase maintain plasma levels above the threshold needed for meaningful tyrosinase inhibition.

Synergy with Topical Depigmenters – The IV drip suppresses melanin systemically while topical agents like hydroquinone, vitamin C serum, or tranexamic acid work directly on surface pigment.

At Claire Derma, the pigmentation drip protocol involves an initial series of eight to twelve weekly sessions to build sustained glutathione levels in the body. Each session takes 30 to 45 minutes. The glutathione concentration is started at the lower end — 1200mg — and increased to 1800mg over the first three sessions as tolerance is confirmed.

Brightens & Evens Out Skin Tone – Reduces dark spots and pigmentation for an even skin tone.

Enhances Skin Radiance – Promotes a youthful and glowing complexion.

Antioxidant Boost – Boosts antioxidant levels to protect skin from environmental damage.

Detoxifies the Body – Flushes out toxins for clearer, healthier skin.

Benefit – Whole-body pigmentation improvement. Unlike topical agents limited to areas of application, IV glutathione and vitamin C circulate systemically, suppressing melanin production across all skin, including hard-to-treat areas like elbows, knees.

Benefit – No topical irritation or skin barrier disruption. Patients with sensitive skin who cannot tolerate hydroquinone, retinoids, or chemical peels can still benefit from pigmentation treatment through IV administration — the.

Benefit – Antioxidant protection that slows future pigmentation development. The sustained antioxidant levels from regular IV infusions reduce oxidative stress — a major trigger for melanocyte activation — providing ongoing protection against.

The primary advantage of IV-delivered depigmenting agents is their systemic reach. Topical treatments only affect the skin they're applied to, leaving body pigmentation and hard-to-reach areas untreated. A PowerGlow drip circulates through every tissue in the body, providing melanin suppression to the face, neck, hands, arms, and trunk simultaneously.

This treatment is ideal for individuals who:

Suffer from hyperpigmentation, melasma, or uneven skin tone.

Want brighter, healthier, and more radiant skin.

Visible skin brightening from PowerGlow pigmentation drips typically becomes noticeable after four to six weekly sessions. The improvement is gradual and cumulative — each session sustains glutathione levels that suppress melanin production, and over weeks the existing pigmented keratinocytes shed naturally while replacements are lighter. At Claire Derma, we photograph patients at baseline, the midpoint, and the end of the initial series to document changes.